Friday, May 17, 2019

Moment-closure approaches to statistical mechanics and inference in models of neural dynamics

At the upcoming SAND meeting in Pittsburgh, I'll be presenting our recent work on using moment closures to combine theoretical models with statistical inference. This work has already been published, but this poster provides a quick summary. 

In my postdoc at Edinburgh, I worked on methods to combine neural field modelling and statistical inference. Neural field models capture how microscopic actions of single neurons combine to create emergent collective dynamics. Statistical modelling of spiking data commonly uses Poisson point-process models. These projects combined the two in an interesting way. 

In "autoregressive point-processes as latent state-space models" [PDF], we convert a popular statistical model for spike-train data into a neural field model. This neural field model is a bit unusual: it extends over time rather than space, and describes correlations as well as mean firing rates. This may lead to new tricks for inference and coarse-graining on these types of models. 

In "neural field models for latent state inference", we use a microscopic model of retinal waves to specify a second-order neural field model that doubles as a latent state-space model for spiking observations. This advances methods for developing data-driven neural field models.

[download poster PDF]